A pathologist determines her2 status by testing a sample of the metastatic tumor (from a biopsy of the metastases) A common clinical challenge — therapeutic pivot for addressing mutations in esr1 gene and more Advanced breast cancer with overexpression and/or amplification of human epidermal growth factor receptor 2 (her2) is a clinically aggressive subtype with poor survival outcomes
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1, 2 however, with the introduction of trastuzumab, the survival rates have greatly improved
1 trastuzumab binds to the extracellular domain iv of her2 preventing its.
