The top and sides of the enzyme are made up of helices, while the bottom is formed by strands of beta sheets and extended hairpin loops. This review discusses got2’s moonlighting roles and its clinical potential. Function, proteins, disorders, pathways, orthologs, and expression.
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Glutamine deprivation or inhibition of mitochondrial aspartate transaminase (got2) results in a profound induction of senescence and a suppression of pdac growth
It is a crucial enzyme that plays a significant role in the metabolism of energy and participates in the detoxification process.
Got2 is a key mitochondrial aminotransferase that links amino acid metabolism to central carbon flux and redox balance in both normal and malignant cells Got2 is upregulated in these cells, supporting tumor growth and protecting against oxidative stress. This multifunctionality positions got2 as a potential target for cancer diagnosis and therapy
