Prb1 (proline rich protein bstni subfamily 1) is a protein coding gene Official gene symbol, which is typically a short form of the gene name, according to hgnc This gene is located on the left arm of chromosome v, near the telomere, positioned between the cin8 and som1 genes.
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We show that saf1 binds the mature protein but ubiquitinates only the zymogen precursor
The ubiquitinated lysine was found to be in a peptide eliminated from the mature protein.
Mechanistically, myc binds to the promoter of the e3 ubiquitin ligase klhl42 and enhances its transcription, leading to rb1 deficiency by inducing both phosphorylated and total prb1. Explore the prb1 gene, its function, mutations, associated disorders, and ongoing research Learn about genetic testing, gene variations, and resources for understanding this important gene.
