Kn026 represents a novel bispecific antibody targeting two distinct her2 epitopes (ecd2 and ecd4), with its structural configuration detailed in supplementary fig The biparatopic her2 antibody design may enhance target binding and contribute to the observed clinical benefit Trastuzumab is a humanized igg1 monoclonal antibody that targets the her2 receptor (also known as her2/neu) that is found on the cell membrane of epithelial cells.
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