However, a relatively small number of proteins (hubs) have a very large number of interacting partners, reaching tens and even hundreds. Our method first generates a set of proximity scores between a protein interaction and sets of cause and effect proteins using a network propagation procedure. Advances in understanding cellular ppis have gone lock step with technological innovations (figure 1).
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Download scientific diagram | the protein and protein interaction networks of all differentially expressed proteins.
In this work, we propose a novel deep learning approach for ppi network orientation
