In the anchor study, the administration of epa at a dose of 4 g/day for 12 weeks reduced the oxidation of ldl by 13.3% compared to the placebo group in patients treated with statins and high triglycerides (from 200 to <500 mg/dl). The objective was to evaluate the effect of docosahexaenoic acid (dha) and eicosapentaenoic acid (epa) on sperm parameters including total sperm concentration, sperm motility, sperm dha, and seminal plasma dha concentration in infertile men. Whilst the risk of cardiac death was reduced with epa plus dha but not epa alone, the risk of mi and major vascular events was reduced only with epa alone and not with the combination.
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This commentary summarizes their pharmacology, efficacy, and safety
