Furthermore, the different roles and possible mechanisms of bclaf1 in tumorigenesis will also be highlighted and discussed. Initial studies indicated a role for this protein as an inducer of apoptosis and. Subsequently, employing coimmunoprecipitation and immunofluorescence, we validated the reciprocal interaction between bclaf1 and cullin 3 (cul3), through which bclaf1 actively upregulates the ubiquitination and degradation of phd2.
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Intriguingly, the targetome includes bclaf1 of which transcription is activated.
Furthermore, by immunohistochemistry, immunofluorescence, and proximity ligation assay, bclaf1 was shown to colocalize (figure 4b) and associate (figure 4c) with bcl2, both in normal media and in plaques, particularly in the fibrous cap region.
Bclaf1 was originally identified as a protein that interacts with antiapoptotic members of the bcl2 family
